Protein Report MAD1_HUMAN
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 Protein Properties
Protein name: MAD1_HUMAN Primary accession number: Q05195
Protein description:
Organism: Homo sapiens Gene name: MXD1
Number of aminoacids: 221 Protein mass [Da]: 25254
Isoelectric point: 8.26 Absorption(280nm) 1g/l protein in 1cm H2O: 0.518
 Protein Description (click to scan for motifs and PTMs)
• Function: Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.
• Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity).
• Subcellular location:
• Similarity: Contains 1 basic helix-loop-helix (bHLH) domain.
 Protein Architecture (click the Pfam domains to see further information)
PfamA domains
PfamB domains
Trans­membrane regions
Signal peptide
Low Complexity
Coiled coil
 Protein Structure (click the pictures to see further information)
 Protein Sequence (export fasta to clipboard (IE) / new page (Mozilla) ; BLAST protein at ExPASy)
MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
Protein Analysis Facility ©2006